Oscar-winning film star Ernest Borgnine dies at 95

Lifetime achievement honoree Ernest Borgnine waves after receiving his award at the 17th annual Screen Actors Guild??Ernest Borgnine, who created a variety of memorable characters in both movies and television and won the best-actor Oscar for his role as a lovesick butcher in "Marty" in 1955, died Sunday. He was 95.

Borgnine's longtime spokesman, Harry Flynn, told The Associated Press that Borgnine died at Cedars-Sinai Medical Center in Los Angeles with his family by his side.

A prolific and talented character actor, Borgnine was known for gruff, villainous roles such as the heavy who beats up Frank Sinatra in "From Here to Eternity" and one of the bad guys who harasses Spencer Tracy in "Bad Day at Black Rock."

Borgnine, who earned a salary of $5,000 for playing his Academy-Award winning role Marty, once said "I would have done it for nothing."

[Related: More on his life, career]

Borgnine, who was born Ermes Effron Borgnino on Jan. 24, 1917 in Hamden, Conn., began acting after serving in the Navy during World War II. He made his film debut in 1951's "Whistle at Eaton Falls" before winning an Academy Award four years later. He appeared in other notable films including "Jubal," "Flight of the Phoenix," "The Dirty Dozen,""The Wild Bunch," "The Poseidon Adventure," "Johnny Guitar," and "Escape from New York."

"No Stanislavsky. I don't chart out the life histories of the people I play," Borgnine told The New York Times in 1973 when asked about his acting methods. "If I did, I'd be in trouble. I work with my heart and my head, and naturally emotions follow."

Sometimes he prayed, he said, or just reflected on character-appropriate thoughts. "If none of that works," he added, "I think to myself of the money I'm making."

He was also known as the Navy officer in the television series "McHale's Navy," which aired from 1962-66. Younger audiences would know him as the voice of Mermaid Man in "Spongebob Squarepants."

Borgnine earned an Emmy Award nomination at age 92 for his work on the series "ER," and was honored with the Screen Actors Guild Life Achievement Award in 2011.

"The Oscar made me a star, and I'm grateful," AP reports that Borgnine told an interviewer in 1966. "But I feel had I not won the Oscar I wouldn't have gotten into the messes I did in my personal life."

The actor was married five times, including to singer Ethel Merman, who became his third wife in 1964. The marriage barely lasted a month.

He is survived by his fifth wife, Tova Traesnaes ? whom he married in 1973 ?his children Christofer, Nancee and Sharon Borgnine; a stepson, David Johnson; six grandchildren; and his sister, Evelyn Verlardi.

Source: http://news.yahoo.com/blogs/upshot/oscar-winning-film-star-ernest-borgnine-dies-la-212606632.html

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NY, Belfast protests try to save death-row dog

By Jim Gold, msnbc.com

A two-year effort to save Lennox, a death-row dog whose owners say was mistaken for a pitbull, sparked an international protest Saturday in Belfast, Northern Ireland, where the animal is slated to be euthanized next week, according to media reports.

UTV in Belfast reported that protesters had flown in from the U.S., England and Dublin.

Protesters organized by No Kill New York animal-saving group plan to target British and Irish consulates Monday in New York to prevent the dog's killing.

The Belfast City Council declared Lennox had a severe personality disorder but his?owners, the Barnes family, say he is a well-handled family pet.

The 7-year-old dog was seized in 2010 as a breed banned under the UK?s Dangerous Dog act.

The dog?s owners say he is an American bulldog-Labrador cross, but dog wardens after measuring his legs and snout declared him a ?possible pitbull type.?

No complaints had been made against the dog, according to media reports.

The Court of Appeal last month rejected a plea spare the dog, being held in a secret location, the Belfast Telegraph reported.?

courtesy photo

Dog trainer and television presenter Victoria Stilwell

Protesters say they are trying to raise awareness not only about Lennox but also to show that ?breed specific legislation? is unfair.

Lennox?s plight is documented on a Save Lennox website and on a Facebook page with more than 75,000 fans. Expressions supporting the dog are also posted on Twitter.

The dog?s cause alsois championed by Victoria Stilwell of ?It?s Me or the Dog? on the Animal Planet network.

Stillwell is consulting with the Barnes family and with Belfast officials to stop the euthanizing and allow the dog to be brought to a new home in the United States.

?It is important to understand that every possible legal avenue to release Lennox back to the family has been exhausted, and that result is no longer an option,? Stillwell posted on her website. ?Indeed, the latest news is that he is scheduled to be euthanized next week. My heart goes out to Craig, Caroline and Brooke [Barnes] for what they are enduring.?

Stillwell has yet to hear back about her efforts, she wrote.

The Barnes family, in a?statement posted on Facebook and the Save Lennox website,??wrote, ?the fight to spare Lennox?s life may well be over. It has been almost impossible for us to accept that we have to admit defeat.?

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Source: http://worldnews.msnbc.msn.com/_news/2012/07/07/12618552-protesters-in-new-york-belfast-try-to-save-lennox-condemned-dog?lite

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Antibodies reverse type 1 diabetes in new immunotherapy study

Friday, July 6, 2012

Scientists at the University of North Carolina School of Medicine have used injections of antibodies to rapidly reverse the onset of Type I diabetes in mice genetically bred to develop the disease. Moreover, just two injections maintained disease remission indefinitely without harming the immune system.

The findings, published online ahead of print (June 29, 2012) in the journal Diabetes, suggest for the first time that using a short course of immunotherapy may someday be of value for reversing the onset of Type I diabetes in recently diagnosed people. This form of diabetes, formerly known as insulin-dependent diabetes mellitus, is an autoimmune disease in which the body's own immune T cells target and destroy insulin-producing beta cells in the pancreas.

The immune system consists of T cells that are required for maintaining immunity against different bacterial and viral pathogens. In people who develop Type 1 diabetes, "autoreactive" T cells that actively destroy beta cells are not kept in check as they are in healthy people.

Senior study author Roland Tisch, PhD, professor of microbiology and immunology at UNC, said a need for effective immunotherapies also exists to treat Type 1 diabetes in people already living with the disease.

"Clinically, there have been some promising results using so-called depleting antibodies in recently diagnosed Type 1 diabetic patients, but the disease process is blocked for only a short period of time," Tisch said. "These antibodies don't discriminate between T cells normally required for maintaining immunity to disease-causing pathogens and the autoreactive T cells. Therefore T cells involved in maintaining normal immune function are also going to be depleted.

"You're getting some efficacy from immunotherapy but its only transient, it doesn't reverse the disease, and there are various complications associated with the use of these depleting antibodies."

Tisch said his UNC lab has been studying the use of certain "non-depleting antibodies." These bind to particular proteins known as CD4 and CD8 expressed by all T cells. Just as the name implies, when these non-depleting antibodies selectively bind to CD4 and CD8 they don't destroy the T cells; the overall numbers of T cells are unaffected.

With this in mind Tisch wanted to determine whether these non-depleting antibodies could have a therapeutic effect in the non-obese diabetic, or NOD mouse, an excellent model for human Type 1 diabetes.

The answer is yes. In some of the recently diagnosed NOD mice, blood sugar levels returned to normal within 48 hours of treatment. Within five days, about 80 percent of the animals had undergone diabetes remission, reversal of clinical diabetes.

"The protective effect is very rapid, and once established, is long-term," he said. "We followed the animals in excess of 400 days after the two antibody treatments, and the majority remained free of diabetes. And although the antibodies are cleared from within the animals in 2-3 weeks after treatment, the protective effect persists." The study showed that beta cells in the NOD mice had been rescued from ongoing autoimmune destruction.

In looking for the mechanism to explain how the therapy worked, the researchers found that the antibodies had a very selective effect on T cells that mediated beta cell destruction. After treatment, "all the T cells that we would normally see in the pancreas or in tissues associated with the pancreas had been purged," said Tisch. This despite the fact that the numbers of T cells found in other tissues and blood were unaffected.

The researchers also found an increase in the numbers of "immune regulatory" T cells. In the healthy individual, these regulatory T cells block autoimmunity, Tisch explained. "They protect us from the autoreactive cells that all of us have. And that's why most of us don't develop autoimmune diseases such as Type 1 diabetes."

"We've demonstrated that the use of non-depleting antibodies is very robust. We're now generating and plan to test antibodies that are specific for the human version of the CD4 and CD8 molecules."

###

University of North Carolina Health Care: http://www.med.unc.edu

Thanks to University of North Carolina Health Care for this article.

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Source: http://www.labspaces.net/121528/Antibodies_reverse_type___diabetes_in_new_immunotherapy_study_

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Dogs May Mourn as Deeply as Humans Do

FRIDAY, July 6 (HealthDay News) -- Jon Tumilson's dog, Hawkeye, was an important part of his life.

And, as it turns out, Tumilson was an important part of Hawkeye's life.

After the Navy SEAL was killed in Afghanistan last summer, more than a thousand friends and family attended the funeral in Rockford, Iowa, including his "son" Hawkeye, a black Labrador retriever who, with a heavy sigh, lay down in front of Tumilson's flag-draped casket. There, the loyal dog stayed for the entire service.

Hawkeye's reaction to his owner's death generated a lot of buzz online and in the media. But it's not unusual, according to pet experts, for some dogs to mourn the loss of a favorite person or animal housemate.

Grief is one of the basic emotions dogs experience, just like people, said Dr. Sophia Yin, a San Francisco-based veterinarian and applied animal behaviorist. Dogs also feel fear, happiness, sadness, anger, as well as possessiveness.

Dogs who mourn may show similar signs to when they're separated for long periods of time from the individual they're bonded to, she said. Of those signs, depression is the most common, in which dogs usually sleep more than normal, move slower, eat less and don't play as much.

The beginnings of such a strong inter-species bond between humans and dogs dates back some 15,000 years, when early man and the ancestor of today's dog roamed the Earth together.

Today, after thousands of years of friendship, there's a great deal of attunement between humans and dogs, not only in terms of comprehension of each other's gestures and body language but also emotionally, said Barbara King, a professor of anthropology at the College of William & Mary in Williamsburg, Va.

It's not just evolutionary logic, or reading peer-reviewed science literature that's convinced King that dogs (as well as cats) feel deep grief. Interviews with astute pet owners for her upcoming book, How Animals Grieve, and the power of observation, has also led her to this conclusion.

Case in point: a grainy video posted on YouTube that captured the image of a scruffy terrier running onto a busy highway in Chile to rescue another dog, hit moments earlier, by a car. As vehicles whiz by the terrier, he instinctively wraps his paws around the injured dog, dragging him off the road to safety.

"When you look at that sort of example, again, you see that these dogs are thinking and feeling creatures, and that sets the stage for grief," she said.

Through her research, King has found that in households with two dogs who've lived together for a number of years, some owners report that when one dog dies, the other gets depressed. Skeptics might point to a change in daily routine as the cause of depression or, perhaps, because the owner is upset and grieving. But King feels differently.

"The surviving dog is searching around the house for a lost companion -- looking in favorite places, going to places that they spent with their friend, very pointed actions that tell you the dog is missing his friend," she said.

In an effort to understand what dogs are thinking, researchers at Emory University in Atlanta are conducting brain scans of dogs using functional MRI (fMRI).

Gregory Berns, director of the Emory Center for Neuropolicy and lead researcher on the project, hopes their work will reveal secrets of the dog-human relationship, from the dog's perspective.

Even with high-tech tools, though, determining whether canines experience grief would be tough, he admitted, because he believes it's unknown how grief looks in the human brain. If it were known, however, Berns said researchers could then look for this emotion in the dog but it would require showing pictures, perhaps movies, of the deceased human or canine.

"It would be fascinating to figure out," said Berns, who normally uses fMRI technology to study how the human mind works. "If I were to speculate, I would guess that, like people, some dogs mourn and others don't."

King agrees. After all, she said, dogs possess unique personalities and react differently, even in the same situation. Whether a dog grieves hinges on a dynamic mix of life experiences, added King, including how they were raised and what their people or animal housemates were like.

If a pet mopes around the house after the death of a canine or human companion, Yin suggests the best thing owners can do is to get their dog's mind off the loss by engaging their pet in fun activities such as a game of fetch, brisk walks and play dates with other pets. "The activity depends on what the dog historically likes," she said.

Don't expect a quick fix. It may take anywhere from a few weeks to a few months, pet experts believe, before a dog's spirits begin to lift.

More information

For more on canine behavior, visit the American Veterinary Medical Association.

Source: http://news.yahoo.com/dogs-may-mourn-deeply-humans-160406576.html

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Obama: jobs figures show must grow economy faster

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Is this a good gaming computer setup? | Diablo 3 Guides ...

Question by : Is this a good gaming computer setup?
I?m looking to build a computer to play WoW, Diablo 3, and maybe Star Wars: Old Republic.
I want to be able to play at good detail with good frame rates. Will this setup work?

Motherboard: ASRock 970 Extreme3
CPU: AMD FX-4100 3.6GHz quad core
RAM: G.Skill Ripjaws X series 16GB
Graphics: EVGA 01G-P3-1566-KR GeForce GTX 550 Ti
HDD: SEagate Barracuda 7200RPM 500GB
Wireless Card: Rosewill RNX-N360PC
OS: Windows 7 Ultimate
Power Supply: 500W included with the case

I don?t want to spend much more than $ 800 because I?m not that hardcore into gaming, just tired of running low frames on low settings. Any feedback on this setup would be nice. Thanks in advance.
Ok changed the graphics from the GTX 550 to a Sapphire Radeon HD 6850, it was about the same cost. The 16GB of ram is because its not much more than 8GB and i don?t feel like upgrading later, also it is 1600 speed. The wireless is because the ethernet cable to my room is long and goes to my xbox too. The modem and the wireless card both support 300Mb speeds over wifi so I?m not worried about that. Windows 7 ultimate is only around 90 dollars on ebay. 500W power supply should easily run a 127W graphics card and a 97W processor, the rest of the setup will be nowhere close to 300W and this case has good reviews, not complaining about bad power supplies.

Best answer:

Answer by Phillip
sounds good to me

Give your answer to this question below!

Source: http://diablo-3-guides.net/is-this-a-good-gaming-computer-setup/

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